Bipolar Disorder: Recent submissions
Now showing items 21-38 of 38
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Patient fibroblast circadian rhythms predict lithium sensitivity in bipolar disorder
(2020-05)Bipolar disorder is a chronic neuropsychiatric condition associated with mood instability, where patients present significant sleep and circadian rhythm abnormalities. Currently, the pathophysiology of bipolar disorder ... -
The effects of intramuscular administration of scopolamine augmentation in moderate to severe major depressive disorder: a randomized, double-blind, placebo-controlled trial
(2020-07)Introduction:Major depressive disorder (MDD) is a common affective disorder. Currently established pharmacotherapies lack rapid clinical response, thereby limiting their ability to bring instant relief to patients. A series ... -
Melatonin In Acute Mania Investigation (MIAMI‐UK). A randomised controlled trial of add‐on melatonin in bipolar disorder
(2020-05)Objectives Current options for treating emergent episodes of hypomania and mania in bipolar disorder are limited. Our objective was to compare the effectiveness and safety of add‐on melatonin in hypomania or mania over ... -
Mania as a possible complication of immunotherapy
(2020-02)Immunotherapy is still a relatively new cancer therapy and this article serves as a reminder to psychiatric teams to consider immunotherapy as a possible factor in psychiatric presentations. Here, the authors present the ... -
Longitudinal cognitive performance in patients with Bipolar Disorder
(2020-01)Commentary: Neurocognitive impairments are a rather common occurrence in euthymic Bipolar Disorder (BD) patients. Understanding the degree of longitudinal stability of these deficits is vital in the management and treatment ... -
Actigraphic patterns, impulsivity and moodinstability in bipolar disorder, borderlinepersonality disorder and healthy controls.
(2020-01)Objectives:To differentiate the relation between the structure and timing of rest-activity patterns and symptoms of impulsivity and mood instability in bipolar disorder (BD), borderline personality disorder(BPD) and healthy ... -
Cyclical Cushing's syndrome and the presentation of a Bipolar Affective state
(2019-12)Affective disorders are relatively frequently observed in patients suffering from endocrine disease. Thus, in Cushing's syndrome, the most common comorbid mental disorder seen is depressive disorder. The rarer cyclical ... -
Cognitive Impairment in Patients with Bipolar Disorder: Impact of Pharmacological Treatment
(2019-12)Bipolar disorder is an illness characterised by periods of elated and depressed mood. These mood episodes are associated with changes in cognitive function and there is evidence to suggest that cognitive dysfunction persists ... -
Smoking and the risk for bipolar disorder: evidence from a bidirectional Mendelian randomisation study
(2019-09)Background:There is increasing evidence that smoking is a risk factor for severe mental illness, including bipolar disorder. Conversely, patients with bipolar disorder might smoke more (often) as a result of the psychiatric ... -
Imagery-Based Cognitive Therapy for Bipolar Disorder and Mood Instability
(Guilford Press, 2019)People with bipolar disorder are particularly vulnerable to anxiety and intrusive mental imagery, which can contribute to mood swings and a heightened risk for relapse. This book presents a novel brief treatment that focuses ... -
Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal
(2019-06)We reappraise the psychiatric potential of calcium channel blockers (CCBs). First, voltage-gated calcium channels are risk genes for several disorders. Second, use of CCBs is associated with altered psychiatric risks and ... -
Comparative economic evaluation of quetiapine plus lamotrigine combination vs quetiapine monotherapy (and folic acid vs placebo) in patients with bipolar depression (cequel)
(2018-12)Although not licensed for acute bipolar depression, lamotrigine has evidence for efficacy in trials and its use is recommended in guidelines. So far there had been no prospective health economic evaluation of its use. ... -
A signature-based machine learning model for distinguishing bipolar disorder and borderline personality disorder
(2018)Mobile technologies offer new opportunities for prospective, high resolution monitoring of long-term health conditions. The opportunities seem of particular promise in psychiatry where diagnoses often rely on retrospective and ... -
Changes in brain Glx in depressed bipolar patients treated with lamotrigine: A proton MRS study
(2019-03)Background Lamotrigine is a useful treatment in bipolar depression but requires several weeks of dose titration before its clinical effects can be assessed. Animal experimental studies suggest that lamotrigine lowers ... -
Experiences of remote mood and activity monitoring in bipolar disorder: a qualitative study
(2017-01)Mobile technology enables high frequency mood monitoring and automated passive collection of date(e.g.actigraphy) from patients more efficiently and less intrusively than has previously been possible. Such techniques are ... -
Plasma glutathione suggests oxidative stress is equally present in early- and late- onset bipolar disorder
(2018-03)We previously demonstrated oxidative stress in bipolar patients and a relationship between the age of illness onset and total glutathione, a principal antioxi- dant. In this study, we sought to replicate these findings ... -
Effectiveness of maintenance therapy of lithium vs other mood stabilizers in monotherapy and in combinations: A systematic review of evidence from observational studies
(2018-02)Objectives: For the first time to present a systematic review of observational studies on the efficiency of lithium monotherapy in comparison with other maintenance mood stabilizers in monotherapy and in combination. Methods: ... -
Modelling suicide in bipolar disorders: Limitations and opportunities
(2018-07)Commentary on: Malhi GS, Outhred T, Das P et al. Modeling suicide in bipolar disorders. Bipolar Disord. 2018. In their paper in this issue, Malhi et al highlight a key clinical area; whilst suicide rates are increased in ...
